![]() palmitate can be taken up from the medium, leading to CO 2 production. At the stationary phase, the parasites fully oxidize fatty acids. Herein, we show that during parasite proliferation, the glucose concentration in the medium can regulate the fatty acid metabolism. In this study, we revisit the metabolic fate of fatty acid breakdown in T. ![]() However, little is known about the possibilities of using externally available and internally stored fatty acids as resources to survive in nutrient-poor environments, and to sustain metacyclogenesis. cruzi to use glucose and amino acids to support the differentiation process occurring in the insect, from replicative non-infective epimastigotes to non-replicative infective metacyclic trypomastigotes. Also established has been the capability of T. cruzi has a flexible metabolism able to rapidly switch from carbohydrates (mainly glucose) to amino acids (mostly proline) consumption. The primary environmental challenge, particularly in the insect stages, is poor nutrient availability. This fact determines the need of adaptations to face challenging environmental cues. cruzi must colonize different niches in order to complete its life cycle in both hosts. Trypanosoma cruzi, the parasite causing Chagas disease, is a digenetic flagellated protist that infects mammals (including humans) and reduviid insect vectors. ![]()
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